Efficacy of massage versus massage with post isometric relaxation in temporomandibular disorders: a randomized controlled trial

Background Temporomandibular joint disorder (TMD) is a common condition affecting the masticatory muscles and joint mobility. Objectives The primary objective was to compare the effects of massage therapy alone and massage therapy combined with post-isometric relaxation exercises in patients with TMD for pain and maximal mouth opening. Design Assessor-blinded randomized controlled trial. Setting Sir Ganga Ram Hospital, Chaudhry Muhammad Akram Dental Hospital, Lahore Medical and Dental Hospital. Subjects Temporomandibular joint disorder patients. Intervention Group A (n = 23) received conventional treatment including massage and therapeutic exercises consecutively for 2 weeks. Group B (n = 23) received post-isometric relaxation technique along with conventional treatment for consecutive 2 weeks. Main measures The main outcome measures were pain and maximal mouth opening. Pain was measured using the Visual Analogue Scale (VAS) and maximal mouth opening (MMO) was measured using the TheraBite Scale. Results Both groups demonstrated significant improvements in pain and MMO scores post-treatment. However, Group B (massage with post-isometric relaxation exercises) showed significantly better outcomes compared to Group A (massage alone). There was a statistically significant difference in post-treatment pain scores (P = 0.000) and MMO scores (P = 0.000) between the two groups. Conclusion The results suggest that massage therapy combined with post-isometric relaxation is more effective than massage therapy alone in managing pain and improving mouth opening in TMD patients. The study provides evidence supporting the use of these therapies in TMD management. Trial registry number NCT05810831. Date of registration/First submission: 15 March 2023. Supplementary Information The online version contains supplementary material available at 10.1186/s13102-024-00865-x.


Background
Temporomandibular disorders (TMD) are a set of heterogeneous neuromuscular and musculoskeletal diseases affecting a large fraction of the global population outlining multitudinous signs and symptoms including myofascial pain, limited joint mobility, joint noise, and impaired orofacial functions: mandibular deviation, swallowing threshold, chewing, speech, yawing and breathing functions [1,2].The prevalence of TMD varies between 7.3 and 30.4% worldwide [3,4].A study in Pakistan showed a 40% prevalence of TMD in young adults [5,6].The temporomandibular classification is complex as it can be due to masticatory muscles, articular problems, hypermobility syndrome, or displaced disc [7,8]Myogenic TMD is most common affecting 43.5% of cases of TMD, principally characterized by myofascial pain in the pre-aural area and limited jaw mobility [9][10][11].Pain is marked by a reduction in blood flow to muscles and muscular activation leading to metabolism by-product accumulation in muscular tissues, causing fatigue and inflammation [1,12].The pain limits joint mobility and decreases maximal mouth opening amplitude thus affecting oral healthrelated quality of life (OHRQoL) in an unrivaled manner [13,14].Over the last few years, the unceasing research on better diagnostic and therapeutic approaches has directed our attention toward the probability of applying non-invasive therapeutic approaches in patients with myogenic TMD [15].Specifically, the alliance between dentistry and physical therapy helps to settle early diagnosis and substantially enhances the effectiveness and accuracy of therapeutic approaches to follow [16][17][18].In physiotherapy management, patient education [19], therapeutic exercises [20] modalities like Transcutaneous Electric Nerve Stimulation TENS [21] Light Amplification by Stimulated Emission of Radiation LASER Therapy [22] and manual therapy [23,24] are promoted.In the literature, there are various types of research done on therapeutic exercise efficacy in enormous sub-acute and chronic musculoskeletal disorders, and is recommended with a combination of manual therapy (MT) in TMD patients [25].Therapeutic exercises and manual therapy in PT interventions are used by researchers and clinicians nowadays due to positive outcomes on TMD patients such as decreased pain and improved joint mobility and function of hypotonic muscles [26].Manual therapy includes soft tissue MT such as myofascial release, postisometric relaxation (PIR), massage and fascial therapy, and joint MT which includes manipulation [27].In soft tissue MT, most scientific evidence emphasizes masticatory muscle massage because it improves blood supply and joint range of motion, relaxes muscles, and reduces pain.On the other hand, PIR is a mobilization technique working on phenomena of excitation and relaxation used nowadays in TMD treatment.It reduces muscle tension by inhibiting muscles' motor neuron field leading to reflex relaxation.The reason is Golgi tendon organs activation when muscles contract.PIR reduces pain, and restores the expected flexibility and length of contracted muscles thus improving joint mobility [7,28,29].Current treatment protocols often rely on a combination of medications, physical therapy, in severe cases, surgery, which may have side effects, are costly, and may not always provide lasting relief while manual therapy has been recognized for its potential benefits in managing TMDs, including pain relief, muscle relaxation, and improved range of motion.However, the comparative effectiveness of massage alone versus massage combined with postisometric relaxation has not been extensively studied.This research aims to fill this gap in knowledge and provide evidence-based recommendations for TMD treatment.By investigating the comparative efficacy of these interventions, the study could lead to the development of more effective, patient-friendly, and cost-effective TMD therapeutic strategies.The primary objective was to compare the effects of massage therapy alone and massage therapy combined with post-isometric relaxation exercises in patients with TMD for pain and maximal mouth opening.It is hypothesized that there is difference in the effects of massage therapy alone and massage therapy combined with post-isometric relaxation exercises in patients with TMD for pain and maximal mouth opening.Further this difference can be used to identify the superior effects of one therapy over the other for management of pain and mouth opening in TMD.

Trial Design and participants
The study was a single assessor-blinded, parallel assigned randomized controlled trial following CONSORT statement guidelines.The study is registered in Clinicaltrials.gov NCT05810831 and the research was carried out in a manner that was compliant with the laws and regulations that had been set by the ethical committee of Superior University.The trial design was parallel 1:1.The

Group allocation
The participants fulfilling inclusion criteria were randomly assigned to Group A and Group B through a random number table.The allocation process was concealed from the researchers and the participants.The process was completed by a research assistant who did not participate in any further research steps.Outcome assessors who were blinded to the treatment groups were recruited to take pre-treatment and post-treatment level readings.Follow-up was taken after 2 weeks of interventions [7].

Inclusion and exclusion criteria
All patients in age of 25-45 both genders went through extraoral and intraoral dental examinations carried out by trained dentists in orofacial pain and the patients fulfilling Group I of RDC/TMD criteria were then referred to physiotherapy treatment [7].Patients with the absence of temporomandibular disc displacement with or without reduction, full dental arches with missing teeth replaced with fixed dental prostheses or full dental arches with natural teeth and good general health (absence of chronic diseases which may affect temporomandibular joint or the muscles of mastication) were included in the study [10] and the patients with earlier splint therapy, injury of masticatory organ, pharmacotherapy (e.g., hormone replacement therapy, oral contraception, and antidepressants), undergoing orthodontic treatment, fibromyalgia and inflammation in the oral cavity (e.g., impacted molars and pulp inflammation) were excluded from the study [7].

Sample size
The sample size was calculated for this research with a 5% margin of error, 95% level of confidence, 80% of power, and effect size (Cohen D) 0.834, and the ratio of sample size Group A / Group B = 1 using the open Epi tool version 3. The mean value for Group A was 4.81 ± 2.01 and for Group B was 6.19 ± 1.2 and variance was 4.040 and 1.44 respectively [30].The calculated sample size was 46 with 23 subjects in each group.(Fig. 1)

Outcome measures
The outcome measures were pain and maximal mouth opening [31].For pain, Visual Analogue Scale was used [1].The intensity of pain was assessed on a 10 cm horizontal line on the Visual Analogue Scale (VAS) in each patient.The left margin of the scale indicates "no pain" Fig. 1 Sample size parameters and the right indicates "most imaginable pain".The scoring is 0-10: 0: no pain.1-3: mild pain.4-6: moderate pain.7-9: severe pain.10: worst pain [30].The test-retest reliability of VAS is good (r = 0.94) For limited joint mobility maximum mouth opening was measured [31].The pain-free maximal distance between the incisal edges of the mandibular central incisor and the maxillary central incisor is referred to as the maximal mouth opening and was measured by the Therabite scale.The scoring of the scale ranges from 0 to 60 mm: 0-40 mm: abnormal 40-45 mm: warning 45-60 mm: normal.The reliability of Therabite scale is excellent (r = 0.92) [32].Follow-up was taken after 2 weeks of interventions [7].

Group A
In Group A participants received conservative physiotherapy protocol including massage twice during a visit for 2 weeks (excluding Saturdays and Sundays) and an exercise program for 2 weeks, 5 sets of 10 repetitions of each exercise daily.The exercise program included exercises such as Gerry's exercise, active exercise for mandible's lateral movement, protrusion, and mouth opening, side-to-side exercise, and active flexion and extension of the cervical spine with instructions on how to perform these exercises were given to each patient.The massage was performed in a supine lying position with a neutrally positioned head.For intraoral massage, the therapist's hand position was "pincer grip", thumb placed outside the mouth, and index finger inside the mouth.10 horizontal movements were carried out from the medial to lateral side of the masseter muscle and 10 vertical movements from the upper to lower side of the muscle.For functional massage, with a pincer grip, the therapist asked the patient to open and close the mouth slowly within the limit of pain and discomfort and performed 10 vertical movements from upper to lower attachment of muscle [7].

Group B
In Group B participants received post-isometric relaxation technique 6 times during a visit, 3 times for adductors, and 3 times for lateral movements for 2 weeks (excluding Saturdays and Sundays) [7] in addition to conservative physiotherapy protocol.Post-isometric relaxation was performed in a supine lying position with a neutrally positioned head [10].To relax the adductors of the mandible, the therapist placed thumbs on the molar and premolar chewing surface of the patient's mouth and abducted the mandible passively, until a functional barrier was reached.The patient performed adductors isometric contraction for 10s using 20% of maximum force and then relaxed muscles and the therapist abducted the mandible to the new functional barrier.Due to the fact that adductors also contract during lateral mandible movement muscles of the mandible for lateral movement also underwent post isometric relaxation technique.The therapist placed one hand on the mandible and stabilized the patient's head with the other hand to counterbalance the muscle contraction performed by the patient.Passive lateral translation of the mandible was carried out and the patient performed 10s isometric contraction using 20% of maximum force towards the starting position.Simultaneously, the therapist stabilized the head and balanced the contraction performed by the patient.After contraction, the patient relaxed the muscles and the therapist deepened the lateral movement of the mandible to a new functional barrier [33].

Data analysis procedure
The SPPS version 20.0 was used for data analysis.The normality was checked using the Shapiro-Wilks test.The p-value statistical significance was < 0.05.The data was not normally distributed, so a non-parametric test was used for comparing outcomes pretest and posttest.The within-group analysis was carried out using Wilcoxon signed ranks and the Mann-Whitney U test was used for between-group compassion at P value < 0.05 (CI 95%).

Results
During the study period 50 patients were enrolled.2 were excluded due to ineligibility and 2 moved out due to personal reasons.(Fig. 2) Out of 46, there were 23 participants in Group A, 8 were male and 15 were female, while in Group B, out of 23 total patients, 6 were male and 17 were female with a P value of 0.522.The mean age of patients in Group A is 36.39 ± 3.57, while in Group B, age is 35.22 ± 2.44.The p-value for age was 0.201.The mean duration of TMD, mean pain score, and mean MMO score p-value show no statistically significant difference between the two groups.It's presented in Table 1.
Pain score: The pre-intervention score was 6.22 ± 0.850 for Group A and 5.83 ± 0.984 for Group B.

Within Group Analysis
For Group A, the pre-treatment pain score was 6.22 ± 0.850, which decreased to 3.30 ± 0.559 posttreatment, showing a significant reduction in pain (Δ = 2.92).For Group B, the pre-treatment pain score was 5.83 ± 0.984, which decreased to 2.48 ± 0.511 post-treatment, showing a significant reduction in pain (Δ = 3.35).Both of these changes were statistically significant (P = 0.000).It's presented in

Within group analysis
For Group A, the pre-treatment MMO score was 35.00 ± 2.256, which increased to 43.30 ± 0.974 posttreatment, showing a significant increase in MMO (Δ = 8.3).For Group B, the pre-treatment MMO score was 35.91 ± 2.795, which increased to 47.04 ± 0.825 post-treatment, showing a significant increase in MMO (Δ = 11.13).Both of these changes were statistically significant (P = 0.000).It's presented in Table 3.

Between-group analysis
The between-group analysis of pain scores and maximal mouth opening (MMO) scores for two groups.4.

Discussions
This assessor-blinded randomized controlled trial conducted at Sir Ganga Ram Hospital, Chaudhry Muhammad Akram Dental Hospital, Lahore Medical and Dental Hospital in Temporomandibular disorder patients.The Group A received conventional treatment including massage and therapeutic exercises and Group received post post-isometric relaxation technique.The results suggested that massage therapy combined with post-isometric relaxation is more effective than massage therapy alone in managing pain and improving mouth opening in TMD patients.Another study concluded that post isometric relaxation is good for temporomandibular joint dysfunction, especially in pain reduction.They also suggested that manual techniques have beneficial effects for masticatory muscles and help in release of endorphins that reduce pain [10].The current study suggested that combination of Physical therapy techniques are effective for TMJ dysfunction.As massage with post isometric relaxation was more beneficial than massage alone in current study.Another study concluded that monotherapy is not effective for TMJ joint dysfunction, as post isometric relaxation with therapeutic exercises and massage with therapeutic exercises were more effective than therapeutic exercises alone [7].In our study after the intervention, both groups showed a significant reduction in pain and an improvement in MMO.However, the group that received massage combined with post-isometric relaxation exercises (Group B) demonstrated significantly better outcomes than the group that received massage alone (Group A).The post-treatment visual analogue scale (VAS) numeric pain rating scores and Maximum Mouth Opening (MMO) scores were both significantly better in Group B. The distribution of patients across the pain and MMO after treatment also differed but non-significantly between the two groups, with a higher proportion of patients in Group B reporting reduction in pain and achieving normal MMO.Another study concluded that there must be a comprehensive plan for physical therapy treatment rather a single technique [31,32].This perspective is same as the current study.Post isometric relaxation is effective for pain and range of motion in TMJ joint dysfunction.Literature supports this concept.
Current study showed significant results with post isometric relaxation technique and massage A systematic review suggested that combination of manual therapy with therapeutic exercise is effective for maximal mouth opening and pain in TMJ joint dysfunction.Therapeutic exercises included isometric exercises [12].This study all supports the concept of current study to use combination of physical therapy techniques for pain and maximal mouth opening in TMJ joint dysfunction.A systematic review concluded that massage is effective for pain in TMJ joint dysfunction [32].Pessoa and fellows utilized a combination of facial massage, dry needling, and laser therapy in their intervention.Their findings indicated an improvement in temporomandibular disorders, which is consistent with the results of our study.However, our study used a different combination of interventions (massage therapy and post-isometric relaxation exercises), suggesting that multiple intervention strategies can be effective for TMD [1].Gębska conducted a similar study examining the efficacy of manual soft tissue therapy and therapeutic exercises in patients with pain and limited TMJ mobility.They also reported positive results, aligning with our findings.However, the difference in the therapeutic exercises used in both studies (post-isometric relaxation exercises vs. other therapeutic exercises) underlines the need for further research to ascertain the best combination of techniques [7].This suggests that the addition of post-isometric relaxation exercises to massage therapy may provide additional benefits in managing pain and limited joint mobility in patients with temporomandibular disorders.In current study, massage therapy and massage combined with postisometric relaxation exercises were effective in reducing pain and improving joint mobility.Prior to the intervention, there were no significant differences between the two groups in terms of age, duration of TMD, gender, initial pain scores, or initial MMO scores.Similarly Herrera-Valenci and colleagues concluded that manual therapy is effective for temporomandibular joint disorders.This supports our findings and confirms that the improvements observed in our study are consistent with a larger body of evidence [25].Current study concluded that massage with post isometric relaxation in temporomandibular disorders is better than massage alone for pain.Urbański highlighted the importance of manual techniques for muscle relaxation in the treatment of TMD.Our study also used a manual technique (massage therapy), and the results support their assertion, further reinforcing the effectiveness of manual techniques in managing TMD [10].In contrast, Asquini focused on predictors of pain reduction following manual therapy.While our study didn't specifically look at predictors, our results do show a significant reduction in pain, thus supporting their thesis that manual therapy is effective [11] Hemashree emphasized conservative treatment modalities in TMD management.Our study used massage therapy and exercises which are conservative treatments, and showed significant improvements, supporting their findings [34].Penlington focused on psychological therapies for TMDs.Although our study did not investigate psychological therapies, the significant improvements in pain and mouth opening observed in our study indicate that a combination of physical and psychological therapies could potentially offer even greater benefits [35].Nagata compared the effectiveness of mandibular manipulation and improved multimodal therapy.The results align with our study as both demonstrated a significant improvement in mouth opening.However, our study used massage and exercises instead of mandibular manipulation, suggesting multiple treatment modalities can be effective [23].Lucena highlighted the effectiveness of manual therapy in older adults.While our study did not specifically focus on older adults, the overall positive results suggest that our intervention could also be effective in this population [26].
De Melo conducted a systematic review focusing on manual therapy for myofascial pain related to TMD.The article found it to be effective, which aligns with our results, further validating the use of manual therapy techniques in managing TMD-related pain [29].Abe investigated the immediate effect of masticatory muscle activity with transcutaneous electrical nerve stimulation in TMD patients.Although our study did not involve electrical stimulation, the positive outcomes in both studies suggest that multiple modalities can contribute to managing TMD effectively [30].Shousha conducted a randomized controlled trial comparing conservative physiotherapy and occlusive splinting.The study found both methods effective in improving pain and range of motion.This supports our results, adding to the evidence that conservative physical treatments can be effective for TMD [36].Further it is suggested that combination of physical therapy, psychological therapy and pharmacological methods should be used for comprehensive treatment.These findings suggests that the addition of post-isometric relaxation exercises to massage therapy, the therapeutic effects were better in combination in reducing pain and improving joint mobility temporomandibular disorders.As the statistical analysis revealed a larger effect size in group B compared to group A, showing combined effect of both interventions greater than group A. As Nagata e et al. stated that massage and exercises due to additive effect are more beneficial suggesting multiple treatment modalities can be predominantly effective [23].

Limitations
This study has some limitations.The study did not evaluate the long-term effects of the interventions, restricting our understanding of the sustainability of the observed improvements.Longitudinal studies should be conducted

Conclusion
The findings from this study suggest that massage therapy and post-isometric relaxation exercises are effective in managing pain and improving mouth opening in patients with temporomandibular disorders.Both Group A and Group B showed significant improvements posttreatment in pain scores, MMO scores.However, the group that received massage combined with post-isometric relaxation exercises (Group B) demonstrated significantly better outcomes than the group that received massage alone (Group A).

Fig. 2
Fig. 2 CONSORT flow chart for enrollment, intervention and follow up Keywords Temporomandibular Joint Disorder, Massage therapy, Post-isometric relaxation exercises, Pain, Maximal mouth opening, Randomized Controlled Trial, Physiotherapy, Masticatory Muscles, Visual Analogue Scale, Therabite Scale

Table 2 .
Maximal Mouth Opening Score: The pre-intervention score was 35.00 ± 2.256 for Group A and 35.91 ± 2.795 for Group B. Tariq et al.BMC Sports Science, Medicine and Rehabilitation (2024) 16:110

Table 1
Demographic profile of participants

Table 2
Within Groups Analysis for Pain and MMO (Wilcoxon Signed Rank Test) *p-value was significant at < 0.05

Table 3
Within Groups Analysis for MMO (Wilcoxon Signed Rank Test)

Massage therapy Group B: Massage therapy plus post- isometric relaxation exercises P-value Mean Rank Sum of Mean Rank Mean Rank Sum of Mean Rank
to assess the long-term effects of the interventions.Another limitation is potential confounding factors such as psychological stress, diet, or other health conditions were not considered, which may impact TMD symptoms.Additional research is needed to explore the impact of potential confounding factors on TMD symptoms and the effectiveness of the interventions.Future studies could compare the effectiveness of different combinations of interventions, as multiple treatment modalities appear to be effective for TMD.Consider integrating physical treatments with psychological therapies to potentially offer even greater benefits for TMD patients.